Genetic causality of circulating inflammatory proteins and plasma metabolites in coronary atherosclerosis

This study provides new insights into the genetic and metabolic mechanisms underlying coronary atherosclerosis, extending beyond traditional biomarkers. The findings highlight potential therapeutic targets of coronary atherosclerosis and related metabolic disorders. Key messages What is already known on this topic: Coronary atherosclerosis, a leading cause of cardiovascular disease, has been linked to inflammatory proteins and plasma metabolites. However, the complexity of these relationships, particularly the genetic and metabolic mechanisms underlying the disease, remains poorly understood. Existing studies have largely focused on individual biomarkers and their associations with atherosclerosis, lacking comprehensive assessments and insights into potential mediation pathways. What this study adds: This study utilizes Mendelian randomization to identify genetic causal relationships between 11 circulating inflammatory proteins and 102 plasma metabolites with coronary atherosclerosis. It provides novel insights into the mediation roles of metabolites like octadecanedioate, C18-DC, and campesterol in the disease's progression. How this study might affect research, practice, or policy: By uncovering genetic and metabolic pathways involved in coronary atherosclerosis, this study lays the groundwork for future therapeutic interventions targeting these pathways. It highlights potential biomarkers and novel therapeutic targets, offering a new perspective on prevention and treatment strategies for coronary atherosclerosis and related metabolic disorders.