A rare case of hepatoid adenocarcinoma of the lung initially presenting as a painful skin nodule

Hepatoid adenocarcinoma of the lung (HAL) is a rare and aggressive subtype of pulmonary adenocarcinoma, with cutaneous metastasis being an uncommon clinical manifestation. A 49-year-old male presented with a painful, nodular skin lesion on the upper back. Histopathological examination confirmed it as a cutaneous metastasis of HAL. Subsequent imaging revealed a large primary tumor in the left lung and widespread metastatic disease. Remarkably, the skin lesion was the initial and only presenting feature. This case illustrates the variable clinical presentation of HAL and underscores the need for thorough evaluation of atypical skin lesions.

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Publication Details

Journal
Journal of Surgical Case Reports
Published
2025-09-01
DOI
https://doi.org/10.1093/jscr/rjaf708
Primary Topic
Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

A rare case of hepatoid adenocarcinoma of the lung initially presenting as a painful skin nodule

Moatasem Hussein Al‐janabi, Mohammad Adib Houreih, Alaa Mahmoud, Fouz Hassan et al.
Journal of Surgical Case Reports
Cancer Diagnosis and Treatment
article

A rare case of hepatoid adenocarcinoma of the lung initially presenting as a painful skin nodule

Moatasem Hussein Al‐janabi, Mohammad Adib Houreih, Alaa Mahmoud, Fouz Hassan, Reem Khabbaza, Ayat Shawish
article en

Abstract

Hepatoid adenocarcinoma of the lung (HAL) is a rare and aggressive subtype of pulmonary adenocarcinoma, with cutaneous metastasis being an uncommon clinical manifestation. A 49-year-old male presented with a painful, nodular skin lesion on the upper back. Histopathological examination confirmed it as a cutaneous metastasis of HAL. Subsequent imaging revealed a large primary tumor in the left lung and widespread metastatic disease. Remarkably, the skin lesion was the initial and only presenting feature. This case illustrates the variable clinical presentation of HAL and underscores the need for thorough evaluation of atypical skin lesions.

Journal of Surgical Case ReportsVol. 2025(9)
Latakia University (SY), Arab Open University (SA)
Openalex Percentile: Top 67%
Cancer Diagnosis and Treatment
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