LC‐MS Analysis and Antimicrobial Activity of Different Extracts of <i>Spondias purpurea</i> L
Abstract Spondias purpurea L. is widely used in folk medicine to treat various pathological conditions. One of its promising activities is antimicrobial. The present work aimed to characterize the composition and evaluate the antifungal and antibacterial effects of aqueous (AESP) and ethanolic (EESP) extracts of leaves. The technique of ultra‐performance liquid chromatography coupled to a quadruple time‐of‐flight system (UPLC‐QTOF) was used for phytochemical qualification. For the antifungal tests, two strains of Candida albicans were used, and for the antibacterial tests, strains of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus were used. Quercetin, Kaempferol, Quinic Acid, gallo (epi)catechin dimer, dehydroascorbic acid, and quercetin derivative were detected in AESP, and quinic acid, iriflofenone 3‐C‐β D glycopyranoside, chlorogenic acid, and stearidonic acid in EESP. It was found that AESP potentiated the action of amikacin against bacteria, and an antifungal effect of both extracts was observed at a concentration of 8,192 µg/mL for the CA URM 4127 strain. The two evaluated extracts significantly potentiated the effect of fluconazole against CA INCQS 40006. The research showed that the extracts tested alone do not present significant antibacterial or antifungal activities at low concentrations against the tested strains. However, they demonstrated potentiating effect of already standardized drugs.
Authors
- Maria Flaviana Bezerra Morais‐Braga (ORCID: https://orcid.org/0000-0002-5898-1257)
- Joara Nályda Pereira Carneiro (ORCID: https://orcid.org/0000-0001-5923-9778)
- Antônia Thassya Lucas dos Santos (ORCID: https://orcid.org/0000-0002-6433-3168)
- Viviane Bezerra da Silva (ORCID: https://orcid.org/0000-0003-0581-2609)
- Jacqueline Cosmo Andrade (ORCID: https://orcid.org/0000-0002-6895-3292)
- Edy Sousa de Brito (ORCID: https://orcid.org/0000-0003-4084-8076)
- Carlos Vinícius Barros Oliveira (ORCID: https://orcid.org/0000-0003-2126-1464)
- Catarina Martins Tahim
- Henrique Douglas Melo Coutinho (ORCID: https://orcid.org/0000-0002-6634-4207)
- Paulo Riceli Vasconcelos Ribeiro (ORCID: https://orcid.org/0000-0002-5258-4015)
- Débora Lima Sales (ORCID: https://orcid.org/0000-0002-3169-0169)
- José Weverton Almeida‐Bezerra (ORCID: https://orcid.org/0000-0002-0966-9750)
- Gyllyandeson de Araújo Delmondes (ORCID: https://orcid.org/0000-0002-9890-9196)
- Maria Elenilda Paulino da Silva (ORCID: https://orcid.org/0000-0002-8451-3887)
- Rafael Pereira da Cruz (ORCID: https://orcid.org/0000-0002-1806-7380)
- Adrielle Rodrigues Costa (ORCID: https://orcid.org/0000-0003-1518-0115)
Institutions
- Brazilian Agricultural Research Corporation (BR)
- Universidade Federal de Pernambuco (BR)
- Universidade Federal do Cariri (BR)
- Universidade Regional do Cariri (BR)
- Fundação Oswaldo Cruz (BR)
- Universidade Federal do Vale do São Francisco (BR)
Publication Details
- Journal
- ChemistrySelect
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/slct.202503127
- Citations
- 1
- Primary Topic
- Essential Oils and Antimicrobial Activity
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Financiadora de Estudos e Projetos
- Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico