Stereotaxic Cisterna Magna Approach for Therapeutic Delivery in a Mouse Model

Source: Joshi, K., et al. Stereotaxic Surgical Approach to Microinject the Caudal Brainstem and Upper Cervical Spinal Cord via the Cisterna Magna in Mice. J. Vis. Exp. (2022)This video demonstrates the cisterna magna stereotaxic approach for targeted delivery to the brainstem and upper spinal cord. By accessing the cerebrospinal fluid-filled cisterna magna, this approach enables precise injections into areas that are difficult to reach using standard stereotaxic methods.