Aquasome: Unlocking Novel Drug Delivery System

Aquasomes are a class of self-assembled nanoparticles with a three-layered structure: a solid nanocrystalline core, a polyhydroxy oligomeric film, and adsorbed bioactive molecules. This design offers advantages over conventional drug delivery systems, particularly in preserving the conformational integrity of delicate biomolecules like peptides, proteins, hormones, and genes. The carbohydrate coating acts as a shield against denaturation and dehydration, crucial for maintaining biological activity., Aquasomes enable targeted delivery and sustained drug release, potentially reducing administration frequency and enhancing therapeutic efficacy. They also improve the solubility of poorly soluble drugs. The core materials, often biodegradable, are generally well-tolerated in the body. This review summarizes the structure, properties, preparation methods, characterization techniques, and applications of Aquasomes in drug delivery.