Efficacy of Hyaluronic Acid Injection Locally on Postoperative Complications after Surgical Removal of Impacted Mandibular Third Molars

Introduction: Odontectomy is a popular dental surgery treatment. However,nerve injury, bone fractures, delayed healing, inflammation, soreness, edema, andtrismus might result. These conditions lower patient quality of life. Many researchreduced post impacted tooth surgical problems. Hyaluronan (HA) is a biomaterial thataccelerates wound healing. Aim: to evaluate efficacy of Hyaluronic acid injectionlocally on control of swelling, pain and trismus in surgical removal of impactedmandibular third molars. Patients and methods: This study was a randomized clinicalcontrol trial and was conducted on 20 adult healthy patients who required surgicalextraction of impacted lower third molar with bilateral, symmetrical lower impactedthird molars that need surgical extraction. Each patient has two sides (right and leftside) one of them was treated by experimental materials (Group B) and the other sidewas left without treatment as a control group. Results: The overall difference in VASwas significant according to groups, Time points, and interaction between groups andtime). Truisms mouth opening (TMO) in the control group showed an average (±SD)of 40.87±7.97, 29.11±9.88, 34.50±8.55, 40.97±8.18; respectively. However, The TMOin the treated group showed an average (±SD) of 40.87±7.97, 34.50±8.07, 37.80±6.46,and 41.38±7.81; respectively. The linear relationship in TMO with time showed a direct(positive) relationship as revealed by simple linear regression. The mean swellingparameters in the control group showed an average (±SD) of 10.51±0.85, 12.12±0.89,11.34±0.54, and 10.76±0.58; respectively. However, the mean swelling parameters inthe treated group and showed an average (±SD) of 10.51±0.85, 11.24±0.78, 10.64±0.85,and 10.17±0.45; respectively. Regression trendline showing the linear correlationbetween time and mean swelling parameters. Conclusion: HA injection after extractionof impacted mandibular third molars has a positive effect on postoperative pain, trismusand swelling.