Exploring The Relationship Between Vitamins B12 and Folic Acid in Newly Diagnosed Cutaneous Wart Patients.

Background: In the field of dermatology, it has been suggested that the combined supplementation of vitamins B12 and folic acid may improve the effectiveness of cutaneous wart treatments. These vitamins play crucial roles in supporting skin health and enhancing immune function, both of which are essential for the body’s ability to fight off viral infections like those causing cutaneous warts. Objectives of study: To determine the potential utility of evaluating vitamin B12, folic acid in newly diagnosed patients with cutaneous warts. Patients and methods: The study included 88 individuals, 38 healthy controls without warts, and 50 patients newly diagnosed with cutaneous warts by a dermatologist. Among the patients, 23 were men and 27 were women, with ages ranging from 10 to 60 years. further subdivided into Group A (25 with plantar warts) and Group B (25 with flat warts), it is worth mentioning that each of the serum vitamin B12 and folic acid was determined by using an enzyme-linked immunosorbent assay. Result: The study found a significant decrease in serum folic acid {with mean ±SD (1.448±0.16) Nmol/L} and B12 levels {with mean ±SD (40,38±17.75) Pmol/L} in cutaneous wart patients with (p ≤ 0.05), compared to serum folic acid (23.49±6.25) Nmol/L and serum vitamin B12 (281.20±115.3) Pmol/L in healthy individuals with (p ≤ 0.05). non-significant differences were observed in vitamin levels between patients with plantar warts or flat warts with (p ≥ 0.05). There was no significant correlation between vitamin B12 and folic acid in either healthy individuals or patients with cutaneous warts (p ≥ 0.05). Conclusion: Research results suggest that folic acid and B12 deficiencies may be linked to the presence of cutaneous warts.