White Blood Cells Parameters in Normal Pregnancy and Severe Preeclampsia

Background: Preeclampsia (PET) is one of the hypertensive disorder in pregnancy (HDP) with different theories explaining etiology and pathophysiology. The actual cause of PET is not well-identified yet . Recently, it has been believed that leukocyte stimulation has a considerable role in PET pathogenesis. Aim: To detect the different changes in parameters of WBCs severe PET in comparison to then normal pregnancy . Methods: This prospective study included 70 pregnant ladies during the third trimester of gestation. Cases were divided into two groups; the Preeclampsia group comprised 35 pregnant women who were clinically and pathologically confirmed with severe preeclampsia , and their blood was drawn in the antenatal period. In contrast, the control group included 35 non-preeclamptic pregnant females. All patients were subjected to entire history taking, clinical examination, ultrasound examination and laboratory investigations, including complete blood count (CBC). Results: A statistically significant difference was recorded between both groups regarding mean SBP, mean DBP, HB, serum creatinine, SGOT, albumin, INR, neutrophils, monocytes and basophils. There was a non-statistically significant difference between the two studied groups concerning white blood cell (WBC) count, lymphocytes and Eosinophils. There was a substantial correlation between WBC count and serum creatinine. Conclusion: This study demonstrated significantly increased values of neutrophils, monocytes, and basophils in PE compared to the control group. Therefore, regular follow-up of haematological parameters could be utilized as indicators in assessing PE severity and could be considered a helpful parameter for preventing PE-related adverse events.