ADJUNCTIVE EFFECT OF PROPOLIS GEL TO NON-SURGICAL STAGE II PERIODONTITIS THERAPY: A CLINICAL AND IMMUNOLOGICAL STUDY

Introduction: Periodontitis affects more than 1/2 of adults over the age of 30.Scaling and root planning is a non-surgical, gold standard that determines importantobjectives to control bacterial infections and reduce inflammation related to periodontalplaque. In recent years, natural products have become increasingly popular; Propolisis a natural material produced by bees and ieffective in treating periodontal disease.Aim: This study was designed to evaluate the effect of propolis gel as an adjunctivenon-surgical treatment on improving clinical parameters (PI, GI) and reducing proinflammatorymediator (IL1, IL6) levels in stage II periodontitis. Methodology: Sixtypatients with stage II periodontitis will be selected from the out- patient clinic of OralMedicine and Periodontology Department, Faculty of Dentistry, Suez Canal University.Moreover, it will be divided randomly into two equal groups. Control group: will receivescaling and root planning only. Test Group: will receive scaling and root planning andpropolis gel adjunctive to non-surgical therapy. At baseline, 1 month and 3 months andfor each group clinical parameters (PI, GI) assessed and proinflammatory mediators(IL1, IL6). Results in the intergroup comparison of IL1 and IL6 levels at different timeintervals, the propolis group showed a statistically significant decrease in IL1 and IL6levels compared to the SRP. The mean IL-1 was lower in the study group than in thecontrol group after 1 month and 3 months. (p-value). In the intergroup comparison ofclinical parameters (Gingival index, plaque index) at different time intervals there isno statistically significant difference. Conclusion: Subgingival delivery of propolis gelshowed enhanced results as an adjunct to SRP in patients with stage II periodontitis asassessed by clinical and biochemical parameters.