Neutrophil to Lymphocyte Ratio as a predictor of myocardial contractility post-ST Segment Elevation Myocardial Infarction in young and middle-aged patients

Background:NLR is known to be more elevated in patient with worse LV systolic function.Aim:detect relation between NLR and GLS in young and middle-aged STEMI patients. Methods:We investigated NLR & GLS in 56 patients during CCU STEMI admission and follow up NLR & GLS were done month later. Percentage of change of follow-up NLR in relation to the baseline admission NLR is calculated in each patient. Results: Baseline NLR shows moderate positive correlation with admission GLS (p<0.001 & r= 0.593) and fair positive correlation with follow-up GLS (p<0.001 & r= 0.481). Follow-up NLR shows moderate positive correlation with follow-up GLS (p<0.001 & r= 0.613). Percentage of NLR decline was related to GLS improvement state with means being about 56.52% in the group whose GLS improved after 1 month and only about 10.16% in the group whose GLS not improved. From. NLR was significantly higher in GLS>-13.8% group 6.06 (5.43±3.45) compared to (2.39±1.05) in GLS≤-13.8% group, p<0.001. By ROC curve,the cut-off value of NLR was 2.547. Multivariate analysis showed patients with higher NLR >2.547 are more probable to develop GLS>-13.8% Conclusion:STEMI patients with high NLR have a greater chance to have worse LV systolic function at MI presentation and after one month