A novel influenza vector-based vaccine expressing ESAT-6 and TB10.4 confers immunity and protection against Bovine tuberculosis in guinea pigs and calves
This novel influenza vector-based vaccine expressing ESAT-6 and TB10.4 antigens elicits strong, long-lasting cellular immunity and provides significant protection against <i>M. bovis</i> infection in guinea pigs and calves. The adjuvant-free formulation demonstrated higher immunogenicity, simplified production, and minimal adverse reactions, positioning it as a promising alternative to BCG for bTB control in livestock.
Authors
- Ainur S. Nurpeisova (ORCID: https://orcid.org/0000-0002-7039-5621)
- Yeraly A. Shayakhmetov (ORCID: https://orcid.org/0000-0002-4486-3188)
- Ruslan Abitayev (ORCID: https://orcid.org/0000-0001-5609-2491)
- Zhandos Abay (ORCID: https://orcid.org/0000-0003-1822-1437)
- Yerbol A. Bulatov (ORCID: https://orcid.org/0000-0001-8543-4219)
- Kuanysh Jekebekov (ORCID: https://orcid.org/0000-0002-7801-6198)
- Kunsulu Zakaryа (ORCID: https://orcid.org/0000-0003-2186-7706)
- Kainar Barakbayev (ORCID: https://orcid.org/0000-0002-7701-5142)
- Nazym Syrymkyzy Syrym (ORCID: https://orcid.org/0000-0002-4361-5676)
- Syrym Kopeyev (ORCID: https://orcid.org/0000-0001-6955-5504)
- Sandugash Sadikaliyeva (ORCID: https://orcid.org/0000-0003-4953-3628)
- Markhabat Kassenov (ORCID: https://orcid.org/0000-0001-6124-703X)
- Kamshat Shorayeva (ORCID: https://orcid.org/0000-0001-8777-8453)
- Makhpal K. Sarmykova (ORCID: https://orcid.org/0000-0002-0650-7457)
- Elina Kalimolda (ORCID: https://orcid.org/0000-0003-4376-7992)
- Bolat Yespembetov (ORCID: https://orcid.org/0000-0003-3312-4045)
- Aisha U. Issabek (ORCID: https://orcid.org/0000-0002-5623-7571)
- Aslan Kerimbayev (ORCID: https://orcid.org/0000-0002-9387-6647)
- Sergazy Sh. Nurabayev (ORCID: https://orcid.org/0000-0003-0843-1983)
- Han Sang Yoo (ORCID: https://orcid.org/0000-0003-0548-0835)
- Zharkinay Absatova (ORCID: https://orcid.org/0000-0003-0510-5496)
- Berik M. Khairullin (ORCID: https://orcid.org/0000-0002-1243-7889)
- S. U. Moldagulova (ORCID: https://orcid.org/0000-0002-8353-1629)
Institutions
- New Generation University College (ET)
- State Research Institute of Highly Pure Biopreparations (RU)
Publication Details
- Journal
- Veterinary World
- Published
- 2025-09-01
- DOI
- https://doi.org/10.14202/vetworld.2025.2573-2589
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education and Science of the Republic of Kazakhstan