Pharmacological and molecular insights into linalool-rich Coriandrum sativum essential oil: Anticonvulsant, analgesic, anti-inflammatory, and antioxidant potential in rodent models
Peruvian CsEO, characterized by a distinctive linalool-rich chemotype, exhibits significant multi-target pharmacological activities, with synergistic contributions from minor constituents enhancing antioxidant and anti-inflammatory effects. Its integrated efficacy profile and favorable safety indicators highlight CsEO as a promising phytotherapeutic candidate for managing seizures, pain, and inflammation. Further studies should explore chronic models, pharmacokinetics, and formulation strategies to optimize clinical applicability.
Authors
- José Manuel Ortiz-Sánchez (ORCID: https://orcid.org/0000-0001-5775-7512)
- Juan Pedro Rojas-Armas (ORCID: https://orcid.org/0000-0003-2355-5976)
- Hugo Jesús Justil-Guerrero (ORCID: https://orcid.org/0000-0002-6465-8747)
- María Elena Salazar-Salvatierra (ORCID: https://orcid.org/0000-0002-5661-4752)
- Jaime Martínez-Heredia (ORCID: https://orcid.org/0000-0001-9636-106X)
- Mariano Gallo Ruelas (ORCID: https://orcid.org/0000-0003-1484-4581)
- Miriam Palomino-Pacheco (ORCID: https://orcid.org/0000-0002-0427-7766)
- Richard Junior Zapata Dongo (ORCID: https://orcid.org/0000-0001-7634-1029)
- Jorge Luis Arroyo-Acevedo (ORCID: https://orcid.org/0000-0002-7695-1908)
Institutions
- National University of San Marcos (PE)
- Instituto de Investigación Nutricional (PE)
Publication Details
- Journal
- Veterinary World
- Published
- 2025-09-01
- DOI
- https://doi.org/10.14202/vetworld.2025.2598-2614
- Primary Topic
- Essential Oils and Antimicrobial Activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad Nacional Mayor de San Marcos