Fibrosis-4 index is related to left atrial volume index in patients with acute coronary syndrome

Objectives: This study aims to evaluate the predictive value of fibrosis-4 (FIB-4) index and left atrial (LA) indices in patients with acute coronary syndrome (ACS). Patients and methods: Between September 2023 and March 2024, a total of 300 consecutive patients with ACS (244 males, 56 females; mean age: 62.7±11.7 years; range, 49 to 78 years) were included in the study. The study group was divided into two groups according to the LA volume index (LAVI) measurements as those with <34 mL/m2 (Group 1, n=226) and those with ≥34 mL/m2 (Group 2, n=74). Demographic, clinical and laboratory data of the patients were recorded. Results: Among a total of 300 patients, 25.6% (n=77) were diagnosed with ST-elevation myocardial infarction (STEMI), 54% (n=162) with non-STEMI (NSTEMI), and 20.3% (n=61) with unstable angina pectoris (USAP). The FIB-4 index was positively associated with the LAVI (odds ratio [OR]=6.419; 95% confidence interval [CI]: 1.505-27.38; p=0.012). In addition, elevated FIB-4 index could predict a LAVI of ≥34 mL/m2 (area under the curve [AUC]: 0.705, p<0.001). Conclusion: An elevated FIB-4 index is correlated with increased LAVI scores, which may serve as a well-established indicator of adverse outcomes and a reliable measure of cardiovascular risk in patients with ACS.