Microinjection-Based Delivery of a Therapeutic Agent into an Awake Rodent Brain

Source: Poland, R. et al. Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior. J. Vis. Exp. (2015)In this video, a water-filled microinjection setup consisting of a syringe and microinjector tubing is used for precise drug delivery. A rat with a pre-implanted guide cannula undergoes targeted brain microinjection, enabling accurate administration of therapeutic agents in awake animals with minimal tissue damage.

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Publication Details

Journal
Journal of Visualized Experiments
Published
2025-08-29
DOI
https://doi.org/10.3791/23839
Primary Topic
3D Printing in Biomedical Research
Type
article
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article

Microinjection-Based Delivery of a Therapeutic Agent into an Awake Rodent Brain

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Journal of Visualized Experiments
3D Printing in Biomedical Research
article

Microinjection-Based Delivery of a Therapeutic Agent into an Awake Rodent Brain

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Abstract

Source: Poland, R. et al. Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior. J. Vis. Exp. (2015)In this video, a water-filled microinjection setup consisting of a syringe and microinjector tubing is used for precise drug delivery. A rat with a pre-implanted guide cannula undergoes targeted brain microinjection, enabling accurate administration of therapeutic agents in awake animals with minimal tissue damage.

Journal of Visualized Experiments
Openalex Percentile: Top 77%
3D Printing in Biomedical Research
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