Targeted Drug Delivery in a Mouse Model via Cisterna Magna Injection

Source: Zamboni, M., et al., Induction of Leptomeningeal Cells Modification Via Intracisternal Injection. J. Vis. Exp. (2020)This video demonstrates the procedure of delivering an inducer drug into the cisterna magna of an anesthetized mouse. The injection selectively induces fluorescent marker expression in brain surface cells accessible via cerebrospinal fluid, confirmed by fluorescence imaging.

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Publication Details

Journal
Journal of Visualized Experiments
Published
2025-08-29
DOI
https://doi.org/10.3791/23894
Primary Topic
Nanoparticle-Based Drug Delivery
Type
article
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article

Targeted Drug Delivery in a Mouse Model via Cisterna Magna Injection

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Journal of Visualized Experiments
Nanoparticle-Based Drug Delivery
article

Targeted Drug Delivery in a Mouse Model via Cisterna Magna Injection

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Abstract

Source: Zamboni, M., et al., Induction of Leptomeningeal Cells Modification Via Intracisternal Injection. J. Vis. Exp. (2020)This video demonstrates the procedure of delivering an inducer drug into the cisterna magna of an anesthetized mouse. The injection selectively induces fluorescent marker expression in brain surface cells accessible via cerebrospinal fluid, confirmed by fluorescence imaging.

Journal of Visualized Experiments
Openalex Percentile: Top 85%
Nanoparticle-Based Drug Delivery
DOISourceOpenAlex
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