Changes in DTI-ALPS index and its associations with neuronal damage in Lewy body disease
DTI-ALPS is reduced in DLB compared to healthy comparators. Our findings suggest that dysfunction of the glymphatic system may contribute to neuronal damage in Lewy body disease. However further research is needed to clarify the role of the glymphatic system, and also the specificity of DTI-ALPS as a marker of glymphatic function.
Authors
- Rory Durcan (ORCID: https://orcid.org/0000-0002-8897-8737)
- John T. O’Brien (ORCID: https://orcid.org/0000-0002-0837-5080)
- Louise Allan (ORCID: https://orcid.org/0000-0002-8912-4901)
- Michael John Firbank (ORCID: https://orcid.org/0000-0002-9536-0185)
- Sally Barker (ORCID: https://orcid.org/0000-0002-2981-3748)
- Alan Thomas (ORCID: https://orcid.org/0000-0002-6667-9533)
- George Petrides (ORCID: https://orcid.org/0000-0001-8734-4049)
- Kirsty Olsen (ORCID: https://orcid.org/0000-0001-5115-8324)
- Joanna Ciafone (ORCID: https://orcid.org/0000-0003-4339-2510)
- Calum A. Hamilton (ORCID: https://orcid.org/0000-0002-9812-3150)
- Nicola Barnett (ORCID: https://orcid.org/0000-0001-7596-7425)
- Paul C. Donaghy (ORCID: https://orcid.org/0000-0001-7195-4846)
- John‐Paul Taylor (ORCID: https://orcid.org/0000-0001-7958-6558)
Institutions
- University of Exeter (GB)
- University of Cambridge (GB)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Parkinsonism & Related Disorders
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.parkreldis.2025.108014
- Citations
- 5
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 4.03