Lymphoma in the breast: a diagnostic and treatment dilemma

Lymphoma involving the breast is an uncommon clinical entity, comprising ˂0.5% of all breast malignancies. Due to its rarity, there is no standardized treatment approach. We describe three patients managed at our centre, each representing a distinct presentation of breast lymphoma: primary breast lymphoma, secondary breast lymphoma, and synchronous disease with concurrent invasive breast carcinoma and lymphoma. Management varied based on histological subtype and disease extent. Therapeutic strategies included combinations of surgery, systemic chemotherapy, and radiotherapy. Each case was discussed in a multidisciplinary tumour board to guide individualized treatment. Breast lymphoma presents diagnostic and therapeutic challenges. Management with multidisciplinary input should be tailored according to lymphoma subtype and patient-specific factors. Further studies are warranted to establish evidence-based treatment protocols.