Impact of Population Pharmacogenomics on Cisplatin‐Induced Neurotoxicities in Testicular Cancer Survivors
African ancestry was associated with increased cisplatin-induced peripheral sensory neuropathy and vertigo versus European ancestry. Population allele frequency differences and expression levels of RNF24, MFSD4B, and REV3L were potentially implicated.
Authors
- Darren R. Feldman (ORCID: https://orcid.org/0000-0003-2424-4635)
- David J. Vaughn (ORCID: https://orcid.org/0000-0002-7319-7719)
- Nancy Jean Cox (ORCID: https://orcid.org/0000-0001-9315-0830)
- Lois B. Travis (ORCID: https://orcid.org/0000-0002-6010-3541)
- Robert Anthony Huddart (ORCID: https://orcid.org/0000-0003-3604-1990)
- Lawrence H. Einhorn (ORCID: https://orcid.org/0000-0001-7971-7669)
- M. Eileen Dolan (ORCID: https://orcid.org/0000-0003-1613-097X)
- Swetha Nakshatri (ORCID: https://orcid.org/0000-0002-7627-1953)
- Paul C. Dinh (ORCID: https://orcid.org/0000-0003-0235-8519)
- Chunkit Fung (ORCID: https://orcid.org/0000-0002-9384-0732)
- Robert J. Hamilton
- C. Kollmannsberger
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- University of British Columbia (CA)
- Princess Margaret Cancer Centre (CA)
- University of Rochester Medical Center (US)
- University of Chicago (US)
- Royal Marsden Hospital (GB)
- Indiana University Indianapolis (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/cam4.71218
- Citations
- 1
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Regeneron Pharmaceuticals
- National Institutes of Health
- National Cancer Institute