Genetic manipulation of OGT enhances NK cell-mediated cytotoxicity in tumor immunity
Stabilization and enhancement of O-GlcNAcylation improve the target-killing capacity of NK cells while overcoming suppressive factors in the TME. These findings highlight advanced strategies, including genetic engineering of O-GlcNAc pathways, as potent approaches to augment NK-based immunotherapies against cancer.
Authors
- Heeyoun Hwang (ORCID: https://orcid.org/0000-0002-0124-2533)
- Tae‐Don Kim (ORCID: https://orcid.org/0000-0002-5910-4264)
- Mi-Ran Song
- Seona Jo
- Se‐Chan Oh (ORCID: https://orcid.org/0000-0003-0088-7580)
- Bong Chan Jeon
- Yu Ri Jung
- Yue Liu (ORCID: https://orcid.org/0000-0002-2700-922X)
- Yunhee Lee
- In-Hwan Jang
- D. An
- Sung-Kyun Park
Institutions
- Korea Basic Science Institute (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.jare.2025.08.062
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00