Qdenga-induced dengue caused by minor DENV-2 subvariant(s) in the vaccine, with two amino acid substitutions in the E protein
Highlight: We describe a Qdenga-induced DENV-2-infection in a Swedish traveller. Comparative sequencing suggests that the vaccine contained a small fraction of identical virus as detected in the patient, suggesting a selection of a DENV-2-substrain with unusual amino acid substitutions. Further research on selection of, and possible effects of, Qdenga-substrain-infections is warranted.
Authors
- John H.‐O. Pettersson (ORCID: https://orcid.org/0000-0001-6665-7492)
- Johan Aarum (ORCID: https://orcid.org/0000-0001-9783-0964)
- Oskar Karlsson Lindsjö (ORCID: https://orcid.org/0000-0003-1068-981X)
- Jonas Klingström (ORCID: https://orcid.org/0000-0001-9076-1441)
- Klara Sondén (ORCID: https://orcid.org/0000-0003-1585-8475)
- Kim Blom (ORCID: https://orcid.org/0000-0002-5286-3735)
- Erica Tibbelin
- Gabriel Heyman
Institutions
- Linköping University (SE)
- Uppsala University (SE)
- Public Health Agency of Sweden (SE)
- Karolinska Institutet (SE)
- Peter Doherty Institute (AU)
- Västmanlands sjukhus Västerås (SE)
- Västerås Municipality (SE)
- Department of Medical Sciences (RU)
- Umeå University (SE)
Publication Details
- Journal
- Journal of Travel Medicine
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1093/jtm/taaf091
- Citations
- 1
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 1.88