Flexible and stable cycle-by-cycle phase-locked deep brain stimulation system targeting brain oscillations in the management of movement disorders
This study presents a flexible and stable pipeline for precise PLDBS with CE-marked devices and a computer-in-the-loop. Using this pipeline, we showed that PLDBS at different STN beta phases differentially modulates the evoked action potentials in the STN and motor behavior used to quantify bradykinesia, paving the way for further studies and clinical trials for PLDBS.
Authors
- Alek Pogosyan (ORCID: https://orcid.org/0000-0003-4791-8153)
- Huiling Tan (ORCID: https://orcid.org/0000-0001-8038-3029)
- Shenghong He (ORCID: https://orcid.org/0000-0002-5269-1902)
- Erlick A C Pereira (ORCID: https://orcid.org/0000-0003-0452-4023)
- Shouyan Wang (ORCID: https://orcid.org/0000-0002-9776-8539)
- Timothy Denison (ORCID: https://orcid.org/0000-0002-5404-4004)
- Laura Wehmeyer (ORCID: https://orcid.org/0000-0003-0280-6756)
- Zixiao Yin (ORCID: https://orcid.org/0000-0001-7088-8031)
- Jean Debarros
- Francesca Morgante (ORCID: https://orcid.org/0000-0002-9834-3639)
- Thomas Hart (ORCID: https://orcid.org/0000-0001-5949-9932)
- Ahmed Raslan (ORCID: https://orcid.org/0000-0002-9551-3612)
- Xuanjun Guo
- Karen Wendt (ORCID: https://orcid.org/0000-0001-7906-4995)
- Fernando Rodriguez Plazas
- Keyoumars Ashkan
Institutions
- Capital Medical University (CN)
- St George’s University Hospitals NHS Foundation Trust (GB)
- University of Oxford (GB)
- Beijing Tian Tan Hospital (CN)
- MRC Brain Network Dynamics Unit (GB)
- King's College Hospital (GB)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- Medical Research Council (GB)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.brs.2025.09.002
- Citations
- 2
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78