Multicomponent Synthesis of Spiro‐Annulated 1,4‐Dihydropyridines from Pyrrole‐2,3‐diones, Malononitrile, and Enamines

Abstract The 1,4‐dihydropyridine scaffold is a key structural motif of numerous drugs and biologically active compounds. This study aimed to develop a synthetic route for accessing spiro‐annulated 2‐amino‐substituted 1,4‐dihydropyridine derivatives to expand their potential applications in drug discovery. A multicomponent reaction strategy was employed to synthesize 2‐amino‐substituted 1,4‐dihydropyridines from pyrrole‐2,3‐diones, malononitrile, and enamines as substrates under 4‐dimethylaminopyridine (DMAP) catalysis. Additionally, enantioselective synthesis was explored using chiral thiourea catalysis. The DMAP‐catalyzed reaction afforded the target 1,4‐dihydropyridines in low to good yields. Under chiral thiourea catalysis, the products were obtained with moderate yields and enantioselectivity (ee ∼40%).