Childhood Obesity Raises GDM Risk Through Adult Obesity: Evidence From Lifecourse Mendelian Randomization Study

Our findings suggest that childhood obesity increases the future risk of GDM primarily through its persistence into adulthood, and that inflammation, as indicated by elevated CRP levels, partially mediates the effect of adult obesity on GDM risk. These results highlight the importance of early obesity prevention and intervention, as well as inflammation control, to reduce the risk of GDM later in life.

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Publication Details

Journal
American Journal of Hypertension
Published
2025-08-14
DOI
https://doi.org/10.1093/ajh/hpaf154
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00
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article

Childhood Obesity Raises GDM Risk Through Adult Obesity: Evidence From Lifecourse Mendelian Randomization Study

Qinyao Huang, Zikai Lin, Kunyi Zhang, Yuying Zhang et al.
1 links
American Journal of Hypertension
Genetic Associations and Epidemiology
article

Childhood Obesity Raises GDM Risk Through Adult Obesity: Evidence From Lifecourse Mendelian Randomization Study

Qinyao Huang, Zikai Lin, Kunyi Zhang, Yuying Zhang, Peishan Tan, Xuyu He, Jialin Lu
article en

Abstract

Our findings suggest that childhood obesity increases the future risk of GDM primarily through its persistence into adulthood, and that inflammation, as indicated by elevated CRP levels, partially mediates the effect of adult obesity on GDM risk. These results highlight the importance of early obesity prevention and intervention, as well as inflammation control, to reduce the risk of GDM later in life.

American Journal of HypertensionVol. 39(1)
Sun Yat-sen University (CN), Shenzhen Maternity and Child Healthcare Hospital (CN), Guangdong Academy of Medical Sciences (CN), Sun Yat-sen University Cancer Center (CN), Guangzhou Medical University (CN)
Openalex Percentile: Top 74%
Genetic Associations and Epidemiology
DOISourceOpenAlex
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Childhood Obesity Raises GDM Risk Through Adult Obesity: Evidence From Lifecourse Mendelian Randomization Study — Qinyao Huang, Zikai Lin, et al. · American Journal of Hypertension (2025) | TGRS Research Map | TGRS