Pharmacokinetic and Pharmacodynamic Interaction of Metformin and Ojeok-san in Healthy Volunteers
Co-administration with OJS decreased the plasma concentrations of metformin compared to that with metformin alone. However, the degree of decrease was not significant based on the geometric mean of the C<sub>max</sub> and AUC<sub>last</sub>. Considering the OGTT results, these changes in metformin concentration did not affect glucose concentration. In addition, there were no significant findings regarding safety profiles.
Authors
- Bo‐Hyung Kim (ORCID: https://orcid.org/0000-0003-3233-2918)
- Sung‐Vin Yim (ORCID: https://orcid.org/0000-0003-4393-800X)
- Sumin Chae (ORCID: https://orcid.org/0000-0001-7888-9098)
- Wang-Seob Shim (ORCID: https://orcid.org/0000-0002-0903-1386)
- Kyung‐Tae Lee (ORCID: https://orcid.org/0000-0002-3141-3727)
- Soo-Young Lee (ORCID: https://orcid.org/0000-0002-4800-4348)
- Minji Kwon (ORCID: https://orcid.org/0009-0001-3558-8516)
Institutions
- Kyung Hee University (KR)
- Kyung Hee University Dental Hospital (KR)
- Kyung Hee University East-West Neo Medical Center (KR)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/dddt.s526915
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kyung Hee University
- Korea Health Industry Development Institute