Green synthesis of magnesium nanoparticle using Mangifera indica seed extract and its anti-cancer activity

The World Health Organization established that cancer is a contributing factor to death in many patients below the age of 70, this calls for the development of better treatment methods. Conventional therapies involving cancer are chemotherapy, radiation therapy, and immunotherapy and have problems like low solubility, high toxicity, and non-target specific cytotoxicity. The research focuses on using metallic nanoparticles for cancer treatment by taking advantage of two unique features associated with the optical properties, biocompatibility, and flexibility in the functionalization of nanoparticles over conventional therapies. This study suggests that improved indigenous treatments are necessary to reduce the illness. Cervical, oral, and colorectal cancers are the most common tumors in women, with breast cancers accounting for most cases. Mangifera indica seed extract was utilized for the green synthesis of magnesium nanoparticles. The formation of magnesium nanoparticles was further confirmed by Ultraviolet-visible spectrophotometry, Fourier-transform infrared spectroscopy, X-ray diffraction, Scanning electron microscopy, and Dynamic Light Scattering. In the present study, anticancer activity was assessed using the HT-29 cell line and the result revealed that IC50 was 33.24 μg/ml for magnesium nanoparticles. At the same time, the actual standard has been 6.88 μg/ml. It can be concluded that the synthesized magnesium nanoparticles have a powerful anticancer activity that makes them promising for further clinical applications.