Hypoxia Inducible Factor‐1α Specific Probe for Tumor Hypoxia Positron Emission Tomography Imaging
A peptide-based, hypoxia-inducible factor-1 α (HIF-1α) specific PET tracer for tumor hypoxia imaging is reported. It was prepared with a rapid Al<sup>18</sup>F labeling method with high stability. Al<sup>18</sup>F-CLLFVY specifically binds to HIF-1α with high affinity and shows higher uptake in cells under hypoxia. Al<sup>18</sup>F-CLLFVY demonstrated comparable tumor uptake to <sup>18</sup>F-FMISO and better contrast.
Authors
- Xiaoyi Guo (ORCID: https://orcid.org/0000-0002-0854-506X)
- Yang Jiang (ORCID: https://orcid.org/0000-0002-7769-3998)
- Zhi Yang (ORCID: https://orcid.org/0000-0003-2084-5193)
- Teli Liu (ORCID: https://orcid.org/0000-0002-7581-7707)
- Nan Li (ORCID: https://orcid.org/0000-0001-8619-7550)
- Qian Zhang (ORCID: https://orcid.org/0000-0003-3032-9088)
- Qian Chen (ORCID: https://orcid.org/0000-0002-1487-5479)
- Hua Zhu (ORCID: https://orcid.org/0009-0009-6719-1044)
- Xianteng Yang (ORCID: https://orcid.org/0000-0002-1303-5283)
- Hao Shen (ORCID: https://orcid.org/0000-0002-2781-2143)
Institutions
- Guiyang Medical University (CN)
- National Medical Products Administration (CN)
- Ministry of Education (ET)
Publication Details
- Journal
- Journal of Labelled Compounds and Radiopharmaceuticals
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/jlcr.4163
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China