Electrospun gelatin sheet reinforced with anti-hypertensive drug for wound healing application

Testing the potential of an electrospun fibrous sheet made with gelatin loaded with the ACE angiotensin converting enzyme inhibitor perindopril (PE-G) was the aim of the investigation. Physico-chemical property analysis was done utilizing Fourier transmission infrared spectroscopy (FTIR), X-ray diffraction (XRD) and Scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDX). Cell migration properties of PE-G in comparison to gelatin scaffold are employing dermal fibroblast cells in vitro. The porosity pattern of the non-woven gelatin sheet was not altered in 1% PE-G, but it was by 3% and 5% PE-loaded gelatin without changes in the elements. FTIR measurements verified the existence of PE and gelatin functional groups in the PE-G scaffold. According to XRD examination, the PE-G fibrous sheet's percentage of crystalline and amorphous nature was altered. Compared to PE-loaded fibrous sheets, gelatin showed a significant cell migratory population. PE-loaded gelatin may be a good option for wound healing applications.