Innate immune cell LXR-β deficiency exacerbates hepatic injury and fibrosis in murine models of primary sclerosing cholangitis
This study indicated innate immune cell LXR-β deficiency can exacerbate hepatic injury and fibrosis in murine models of PSC suggesting that LXR-β may regulate the function of innate immunity in the fibrotic advancement of PSC.
Authors
- Feng Zhang (ORCID: https://orcid.org/0000-0002-7812-6645)
- Yang Zhang (ORCID: https://orcid.org/0009-0000-5159-1881)
- Ziliang Ke (ORCID: https://orcid.org/0000-0002-2461-2410)
- Fangyuan Cong
- Junyao Wang (ORCID: https://orcid.org/0000-0002-7614-5615)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-0135-392X)
- Jianhua Zhou (ORCID: https://orcid.org/0009-0008-9627-6517)
- Yulan Liu (ORCID: https://orcid.org/0000-0001-8748-9803)
- Jun Xu (ORCID: https://orcid.org/0000-0002-4300-4824)
- Xiaohui Fang (ORCID: https://orcid.org/0000-0003-2731-5021)
- Shan Cao
- Huiting Su
- Yin Lin
Institutions
- Peking University (CN)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- Liver Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.livres.2025.09.001
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality
- Peking University
- Capital Health Research and Development of Special Fund