Correlation Between Blood Transforming Growth Factor-Beta 1 (TGF-β1) Levels and Cardiac Function Parameters Following Doxorubicin Chemotherapy

This study found no significant correlations between TGF-β1 and EF, E/A, E/E', TAPSE, or GLS in the overall cohort. In patients who had received a cumulative doxorubicin dose ≥600 mg/m², TGF-β1 correlated significantly with E/E'. As a profibrotic cytokine, TGF-β1 contributes to myocardial fibrosis, increasing stiffness and filling pressures, which may be best captured by E/E' rather than systolic indices. These findings suggest that higher cumulative anthracycline exposure may enhance cardiotoxicity risk and highlight TGF-β1 as a potential biomarker of anthracycline-induced cardiac fibrosis.