Transcriptomic and Metabolomic Signatures of Acute Circadian Misalignment in Mice
Acute circadian misalignment, such as that induced by a single episode of jet lag, can leave molecular traces even after behavioral rhythms appear to recover. Here, we applied an integrated multi-omics approach-combining liver transcriptomics and plasma metabolomics-to characterize residual signatures on the 7th day after a single 6-h phase advance in male mice. Our data revealed significant alterations, particularly in the core clock genes Bmal1 and Cry1, and the metabolites l-arginine and SM(d18:1/18:1(11Z)), with notable differences at Zeitgeber Time 0 (ZT0). Additionally, we identified l-Serine as a potential biomarker for circadian misalignment, independent of sampling time. These findings provide new insights into potential biomarkers for detecting acute circadian misalignment.
Authors
- Baoyin Ren (ORCID: https://orcid.org/0000-0003-4563-3496)
- Youfei Guan (ORCID: https://orcid.org/0000-0002-5231-0209)
- Le-Jia Qiu (ORCID: https://orcid.org/0000-0002-5369-4988)
- Jiazhi Li (ORCID: https://orcid.org/0009-0000-6231-2200)
- Zhaiyi Liu
- Changxiao Ma (ORCID: https://orcid.org/0000-0002-7464-8884)
- Huiwen Zheng (ORCID: https://orcid.org/0000-0002-6056-3468)
- Bingyi Shen (ORCID: https://orcid.org/0000-0003-4169-8997)
- Jingwen Zhu
- Meina Guo
- Xiaoyan Zhang (ORCID: https://orcid.org/0000-0002-0646-4418)
- Hui Wang (ORCID: https://orcid.org/0000-0003-2791-8981)
- Lihong Chen (ORCID: https://orcid.org/0000-0001-6370-1865)
- Haonan Li (ORCID: https://orcid.org/0000-0003-1954-641X)
- Jiayang Zhang (ORCID: https://orcid.org/0000-0003-3865-9735)
- Guangrui Yang
- Yingzhi Huang
- Hongmei Tan
- Jiaxin Liu (ORCID: https://orcid.org/0009-0000-5496-3011)
Institutions
- Dalian Medical University (CN)
- Fudan University (CN)
- Dalian University of Technology (CN)
- Dalian University (CN)
- Wuhu Fourth People Hospital (CN)
- Shanghai University of Medicine and Health Sciences (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Journal of Pineal Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1111/jpi.70075
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00