A neural circuit from paraventricular hypothalamic nucleus oxytocin neurons to trigeminal nucleus caudalis GABAergic neurons modulates pain sensitization in a mouse model of chronic migraine
PVN OXT neurons exert a descending facilitatory effect on GABAergic neurons in the TNC via OXT release, thereby ameliorating pain sensitization in chronic migraine.
Authors
- Wangyuan Zou (ORCID: https://orcid.org/0000-0003-4813-2806)
- H. Isaac Chen (ORCID: https://orcid.org/0000-0002-7431-6046)
- Jiang Bian (ORCID: https://orcid.org/0000-0001-9610-0847)
- Xu‐Feng Xu
Institutions
- Qingdao University (CN)
- Marine Biology Institute of Shandong Province (CN)
- Panzhihua Central Hospital (CN)
- Marine Biomedical Research Institute of Qingdao (CN)
- Qujiang People's Hospital (CN)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Journal of Zhejiang University (Medical Sciences)
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3724/zdxbyxb-2025-0211
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology of Sichuan Province
- Health Commission of Sichuan Province