ROS and Drp1-mediated mitochondrial fission contributes to the hyposalivation caused by Sjögren’s disease
The elevated ROS in SGECs participates in hyposalivation in SjD. The excess ROS results in the increased mitochondrial fission via Drp1 and its Ser616 site, further worsening mitochondrial dysfunction in glandular cells. Mdivi-1 intraductal infusion significantly can ameliorate hyposalivation in murine models of SjD.
Authors
- Zhihao Du (ORCID: https://orcid.org/0000-0002-8973-761X)
- Wei‐Xia Chu
- Chong Ding (ORCID: https://orcid.org/0000-0002-1834-4421)
- Shan Zhang (ORCID: https://orcid.org/0000-0002-3340-3768)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-1551-5782)
- Xiaopeng Shan
Institutions
- Peking University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Shanghai Stomatological Hospital (CN)
- National Clinical Research (US)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1097/cm9.0000000000003727
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00