Peripheral blood mesenchymal stem cell‐derived exosomes improve renal sympathetic denervation efficacy through β‐catenin‐mediated cardiac reprogramming
Myocardial infarction triggers cardiomyocyte depletion and sympathetic overactivation, culminating in irreversible heart failure. Renal denervation (RD) attenuates sympathetic signalling, modulating catecholamine‒B-type natriuretic peptide (BNP) homeostasis. We newly demonstrate RD-enhanced peripheral blood mesenchymal stem cell exosomal secretion enriched with miR-141-200-429 clusters. These exosomal miRNAs suppress dickkopf-1 (Dkk1), activating GSK3β/Wnt/β-catenin signalling to enhance myocardial survival and regeneration. Our findings establish a combined therapeutic paradigm wherein RD maintains durable efficacy and safety alongside complementary interventions for heart failure management.
Authors
- Pengzhen Wang (ORCID: https://orcid.org/0000-0002-6603-3206)
- Jianshuo Wang
- Lan Zhao (ORCID: https://orcid.org/0000-0003-2681-7695)
- Zhanyu Deng
- Shaoheng Zhang (ORCID: https://orcid.org/0000-0002-4768-0088)
- Yanwen Deng
- Li Chen (ORCID: https://orcid.org/0000-0001-5345-1620)
- Zhichuan Huang
Institutions
- Jinan University (CN)
- Nanfang Hospital (CN)
- Dahua Hospital (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/ctm2.70475
- Citations
- 2
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Natural Science Foundation of China