Pain Catastrophising Amplifies Parietal Responses to Painful Laser Stimulation in Healthy Controls
Pain catastrophising was associated with amplified laser-evoked potential (LEP-N2P2) responses during painful, but not non-painful, stimulation in healthy adults. The effect was localised to the parietal midline, strongest for the first stimulus in a sequence, and diminished with repetition. These findings suggest modality-dependent cortical modulation and highlight LEP-N2P2 as a potential neural marker of maladaptive pain processing.
Authors
- Chang‐Chia Liu (ORCID: https://orcid.org/0000-0002-2990-739X)
- Shuqi Ye
- Mark Quigg (ORCID: https://orcid.org/0000-0003-3035-9260)
- Patrick H. Finan (ORCID: https://orcid.org/0000-0002-7525-4801)
- Dan Wang (ORCID: https://orcid.org/0000-0003-3421-697X)
- Xiaohan Zhang (ORCID: https://orcid.org/0000-0002-3067-7317)
- W. Jeffrey Elias
- Shayan Moosa
- Patrick Realyvasquez
Institutions
- Neurological Surgery (US)
- University of Virginia (US)
Publication Details
- Journal
- European Journal of Pain
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1002/ejp.70117
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00