Antagonizing Viral MicroRNAs Reduces Ocular HSV-1 Pathogenesis and Enhances Mucosal Immune Homeostasis
HSV-1 v-miRs act as key immunoregulatory effectors during acute corneal infection. Their targeted inhibition using LNA-based therapy mitigates inflammation and promotes immune regulation, highlighting a novel therapeutic strategy for ocular HSV-1 disease.
Authors
- Hemant P. Borase (ORCID: https://orcid.org/0000-0003-2097-1018)
- Araceli Valverde (ORCID: https://orcid.org/0000-0001-6044-0209)
- Chandrashekhar D. Patil (ORCID: https://orcid.org/0000-0002-5641-4523)
- Deepak Shukla (ORCID: https://orcid.org/0000-0002-3039-6953)
- Raza Ali Naqvi (ORCID: https://orcid.org/0000-0003-0187-2081)
- Afsar Raza Naqvi (ORCID: https://orcid.org/0000-0001-7436-3056)
Institutions
- Illinois College (US)
- University of Illinois Chicago (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1167/iovs.66.12.16
- Citations
- 2
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Institutes of Health