Lipidomic Signature of Abdominal Aortic Aneurysm and Peripheral Artery Disease

Vascular diseases are powerful predictors of cardiovascular mortality, but they are typically under-recognized and undertreated. There is no effective treatment for either abdominal aortic aneurysm (AAA) or peripheral artery disease (PAD). Lipids are key molecules in cardiovascular diseases and good candidates for diagnosis, monitoring, and risk prediction; nonetheless, there is very limited information on the lipidomic profile of patients with AAA and PAD. We hypothesize that lipids can be used as important prognostic biomarkers of these diseases. To achieve this, we conducted a comprehensive C18 reversed-phase (RP) liquid chromatography-tandem mass spectrometry (LC-MS) lipidomic analysis of plasma from AAA and PAD patients undergoing open repair surgery, comparing their profiles with those of healthy controls. We observed a marked reduction in PAD and AAA of the relative abundances of (i) phospholipids bearing polyunsaturated fatty acids, primarily from the phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI) classes, mostly due to oxidative degradation, and (ii) plasmalogen species of PC and PE, which serve as endogenous antioxidants. On the other side, SM and Cer increased in both pathologies. Our findings suggest a dysregulation of the lipid metabolism in AAA and PAD compared with healthy controls that deserves exploration to unravel putative biomarkers or disease hallmarks.

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Publication Details

Journal
Journal of Proteome Research
Published
2025-09-05
DOI
https://doi.org/10.1021/acs.jproteome.5c00293
Primary Topic
Aortic aneurysm repair treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Lipidomic Signature of Abdominal Aortic Aneurysm and Peripheral Artery Disease

Helena Beatriz Ferreira, Tânia Melo, Venkat Ayyalasomayajula, Rita Nogueira‐Ferreira et al.
Journal of Proteome Research
Aortic aneurysm repair treatments
article

Lipidomic Signature of Abdominal Aortic Aneurysm and Peripheral Artery Disease

Helena Beatriz Ferreira, Tânia Melo, Venkat Ayyalasomayajula, Rita Nogueira‐Ferreira, M. Rosário Domingues, Adelino Leite‐Moreira, Laura Goracci, Marina Dias‐Neto, Rita M. Ferreira, Inês M. S. Guerra, Kak Khee Yeung, Fábio Trindade, Tara van Merrienboer
article en

Abstract

Vascular diseases are powerful predictors of cardiovascular mortality, but they are typically under-recognized and undertreated. There is no effective treatment for either abdominal aortic aneurysm (AAA) or peripheral artery disease (PAD). Lipids are key molecules in cardiovascular diseases and good candidates for diagnosis, monitoring, and risk prediction; nonetheless, there is very limited information on the lipidomic profile of patients with AAA and PAD. We hypothesize that lipids can be used as important prognostic biomarkers of these diseases. To achieve this, we conducted a comprehensive C18 reversed-phase (RP) liquid chromatography-tandem mass spectrometry (LC-MS) lipidomic analysis of plasma from AAA and PAD patients undergoing open repair surgery, comparing their profiles with those of healthy controls. We observed a marked reduction in PAD and AAA of the relative abundances of (i) phospholipids bearing polyunsaturated fatty acids, primarily from the phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI) classes, mostly due to oxidative degradation, and (ii) plasmalogen species of PC and PE, which serve as endogenous antioxidants. On the other side, SM and Cer increased in both pathologies. Our findings suggest a dysregulation of the lipid metabolism in AAA and PAD compared with healthy controls that deserves exploration to unravel putative biomarkers or disease hallmarks.

Journal of Proteome ResearchVol. 24(10)
Universidade do Porto (PT), University of Perugia (IT), RISEBA University of Applied Sciences (LV), Administração Regional de Saúde de Lisboa e Vale do Tejo (PT), Anglo American (United Kingdom) (GB), Rede de Química e Tecnologia (PT), Amsterdam University Medical Centers (NL), Institute for Atherosclerosis Research (RU), Centro Universitário de João Pessoa (BR), University of Aveiro (PT), Vrije Universiteit Amsterdam (NL), University of Amsterdam (NL)
European Cooperation in Science and Technology, Fundação para a Ciência e a Tecnologia, HORIZON EUROPE Health
Openalex Percentile: Top 65%
Aortic aneurysm repair treatments
DOIOpen Access PDFOpenAlex
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