Identification of robust associations between admission microbiome profiles and complications of acute pancreatitis
Three admission microbiome taxa associated with severity and complications were highly robust, although their biological relevance remains unclear. This study also shows the lack of replicable findings of admission microbiome associations, highlighting the need for longitudinal studies to establish temporal relationships between microbiome changes and disease progression.
Authors
- Marco Brayda‐Bruno (ORCID: https://orcid.org/0000-0002-8608-0114)
- Roy L.J. van Wanrooij (ORCID: https://orcid.org/0000-0003-0477-4532)
- Rogier P. Voermans (ORCID: https://orcid.org/0000-0002-9969-019X)
- Hjalmar C. van Santvoort (ORCID: https://orcid.org/0009-0007-1218-2883)
- Pieter Jan F. de Jonge
- Marc G. Besselink (ORCID: https://orcid.org/0000-0003-2650-9350)
- Robert C. Verdonk (ORCID: https://orcid.org/0000-0001-5591-0499)
- Peter van Duijvendijk (ORCID: https://orcid.org/0000-0002-0441-6180)
- Marja A. Boermeester (ORCID: https://orcid.org/0000-0003-3890-8105)
- Adriaan C.I.T.L. Tan (ORCID: https://orcid.org/0000-0002-7389-5437)
- Erwin-Jan M. van Geenen
- Fons F. van den Berg (ORCID: https://orcid.org/0000-0001-6494-4287)
- Matthijs P. Schwartz (ORCID: https://orcid.org/0000-0003-3106-3373)
- Yama Issa (ORCID: https://orcid.org/0000-0002-0191-8871)
- Elske Sieswerda (ORCID: https://orcid.org/0000-0001-5819-4918)
- Hester C. Timmerhuis (ORCID: https://orcid.org/0000-0001-5714-4951)
- Ben Witteman (ORCID: https://orcid.org/0000-0002-1341-8540)
- Merel M. Tielemans
- Rutger Quispel (ORCID: https://orcid.org/0000-0002-6109-9310)
- Harry van Goor (ORCID: https://orcid.org/0000-0003-0323-4876)
- Niels G. Venneman (ORCID: https://orcid.org/0000-0002-9418-057X)
- Jeanin E. van Hooft (ORCID: https://orcid.org/0000-0002-4424-0079)
- Alexander C. Poen
- Tessa E H Römkens (ORCID: https://orcid.org/0000-0002-4184-9823)
- Jeroen M. Jansen
- Marie Paule G F Anten
- Muhammed Hadithi
- Wim van de Vrie
- Hannah S Pauw (ORCID: https://orcid.org/0009-0003-2487-8192)
Institutions
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Leiden University Medical Center (NL)
- Gelre Hospitals (NL)
- Medisch Spectrum Twente (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Sint Franciscus Gasthuis (NL)
- Albert Schweitzer Ziekenhuis (NL)
- Reinier de Graaf Hospital (NL)
- St. Antonius Ziekenhuis (NL)
- OLVG (NL)
- Amsterdam Neuroscience (NL)
- Maasstad Ziekenhuis (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Ziekenhuis Gelderse Vallei (NL)
- Isala (NL)
- Amsterdam University Medical Centers (NL)
- Meander Medisch Centrum (NL)
- Jeroen Bosch Ziekenhuis (NL)
- Bravis Ziekenhuis (NL)
- University of Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- BMJ Open Gastroenterology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1136/bmjgast-2025-001961
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Maag Lever Darm Stichting