Differential Chromatin Accessibility, Gene Expression, and mRNA Splicing Between Developing Cochlear Inner and Outer Hair Cells
Differential transcriptomes between developing hair cell types result from pre- and post-transcriptional mechanisms. The unique promoters and mRNA isoforms in cochlear HCs highlight the importance of elucidating transcriptomes and epigenomes of rare cell types. We provide a comprehensive resource for the identification of promoters and mRNA isoforms of genes expressed by neonatal IHCs or OHCs, which is publicly-accessible for visualization of any gene of interest at https://igvviewer.s3.us-east-2.amazonaws.com/index.html .
Authors
- Anne Duggan (ORCID: https://orcid.org/0000-0002-4922-289X)
- Chuan Zhi Foo (ORCID: https://orcid.org/0000-0003-2663-0257)
- Elizabeth T. Bartom
- Jaime Garcı́a-Añoveros (ORCID: https://orcid.org/0000-0001-6561-9048)
- Litao Tao (ORCID: https://orcid.org/0000-0002-9801-6515)
Institutions
- Northwestern University (US)
- Creighton University (US)
- Northwestern University (PH)
Publication Details
- Journal
- Journal of the Association for Research in Otolaryngology
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1007/s10162-025-01005-z
- Citations
- 1
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 1.46
Funders
- University of Southern California
- National Institute on Deafness and Other Communication Disorders