Role of PAI-1 in the progression and treatment resistance of non-small cell lung cancer
PAI-1 is a key regulator of tumor progression and therapeutic resistance in NSCLC. Targeting PAI-1 may offer a novel strategy to overcome resistance to multiple treatment modalities, and future research should focus on developing PAI-1-based biomarkers and therapeutic combinations for both NSCLC.
Authors
- Noboru Hattori (ORCID: https://orcid.org/0000-0002-8234-942X)
- Takeshi Masuda (ORCID: https://orcid.org/0000-0003-3557-0049)
Institutions
- Hiroshima University (JP)
- Hiroshima University Hospital (JP)
Publication Details
- Journal
- Biomedical Journal
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1016/j.bj.2025.100911
- Citations
- 2
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.87