Simultaneous profiling of the blood and gut T and B cell repertoires in Crohn’s disease and symptomatic controls illustrates tissue-specific alterations in the immune repertoire of individuals with Crohn’s disease
Our findings highlight the importance of studying the immune repertoire in a tissue-specific manner and the need to profile the T and B cell immune repertoire of gut tissues as not all disease-induced alterations will be detected in the blood.
Authors
- Gøri Perminow (ORCID: https://orcid.org/0000-0002-4158-372X)
- Corinna Bang (ORCID: https://orcid.org/0000-0001-6814-6151)
- Aya K.H. Mahdy (ORCID: https://orcid.org/0009-0009-6115-4429)
- Petr Ricanek (ORCID: https://orcid.org/0000-0003-2454-7388)
- Marte Lie Høivik (ORCID: https://orcid.org/0000-0002-0104-465X)
- Gert Huppertz‐Hauss (ORCID: https://orcid.org/0000-0002-5693-8773)
- Florian Tran (ORCID: https://orcid.org/0000-0002-3735-9872)
- Tone Bergene Aabrekk
- Vendel A. Kristensen (ORCID: https://orcid.org/0000-0002-0876-8634)
- André Franke (ORCID: https://orcid.org/0000-0003-1530-5811)
- Mathilde Poyet (ORCID: https://orcid.org/0000-0001-6905-9017)
- Hesham ElAbd (ORCID: https://orcid.org/0000-0003-1844-8279)
- May‐Bente Bengtson (ORCID: https://orcid.org/0000-0002-5615-7141)
- Randi Opheim (ORCID: https://orcid.org/0000-0002-0513-1435)
- Johannes R. Hov (ORCID: https://orcid.org/0000-0002-5900-8096)
- Trond Espen Detlie (ORCID: https://orcid.org/0000-0002-1576-5298)
- Valentina Schöpfel
Institutions
- Oslo University Hospital (NO)
- Lithuanian University of Health Sciences (LT)
- Norwegian Institute of Public Health (NO)
- University of Oslo (NO)
- Akershus University Hospital (NO)
- Sykehuset i Vestfold (NO)
- Hochschule für Angewandte Wissenschaften Kiel (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Lovisenberg Diakonale Høgskole (NO)
- University Hospital Schleswig-Holstein (DE)
- Telemark Hospital (NO)
- Clinical Research Center Kiel (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1638522
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Deutsche Forschungsgemeinschaft
- HORIZON EUROPE Framework Programme