Severe fatigue is associated with diminished lung function and elevated Galectin-9 levels in early systemic sclerosis
Severe fatigue in SSc patients is associated with increased disability, reduced pulmonary function and increased vascular remodeling. We propose that ME/CFS-like symptoms in patients with SSc may be indicative of sub-clinical inflammation and fibrosis. Further studies are required to determine whether Gal-9,may be a useful tool for the stratification of SSc patients - particularly those with severe fatigue resembling ME/CFS.
Authors
- Jan Willem Cohen Tervaert (ORCID: https://orcid.org/0000-0001-7407-6364)
- Robert Gniadecki (ORCID: https://orcid.org/0000-0002-2310-8300)
- D. Sholter
- Marvin J. Fritzler (ORCID: https://orcid.org/0000-0003-1652-6608)
- Janet Pope (ORCID: https://orcid.org/0000-0003-1479-5302)
- Sabrina Hoa (ORCID: https://orcid.org/0000-0002-9466-5729)
- May Y. Choi (ORCID: https://orcid.org/0000-0003-3760-2737)
- Lamia Khan (ORCID: https://orcid.org/0000-0002-5157-2207)
- Shokrollah Elahi (ORCID: https://orcid.org/0000-0002-7215-2009)
- M.S. Osman (ORCID: https://orcid.org/0000-0002-5783-0940)
- Erin S. Reynolds (ORCID: https://orcid.org/0000-0002-2847-0982)
- Maryam Rezaeifar
- Murray Baron (ORCID: https://orcid.org/0000-0002-0435-6165)
- Charmaine van Eeden (ORCID: https://orcid.org/0000-0002-2533-7430)
- Andrew L. Mason (ORCID: https://orcid.org/0000-0002-0470-9522)
- Maggie Larché (ORCID: https://orcid.org/0000-0002-9506-1249)
- Douwe J. Mulder (ORCID: https://orcid.org/0000-0003-3715-6474)
- Desiree Redmond (ORCID: https://orcid.org/0000-0002-9379-051X)
- Ajantha Abey (ORCID: https://orcid.org/0000-0003-0484-8001)
- Carter Thorne (ORCID: https://orcid.org/0000-0002-1721-190X)
- Shima Shahbaz
- Elena Nethchiporouk
- Muhammad Elezzabi
Institutions
- Western University (CA)
- Alberta Health Services (CA)
- University of Alberta (CA)
- University of Calgary (CA)
- University of Groningen (NL)
- University of Toronto (CA)
- McGill University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1655414
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Arthritis Society
- University of Alberta
- Nierstichting
- Institute of Musculoskeletal Health and Arthritis