Population pharmacokinetics of a single oral dose of gabapentin identifies rapid plasma clearance in rehabilitated Pacific harbor seal pups (Phoca vitulina richardii)
Gabapentin was rapidly absorbed and eliminated in HSs, indicating that higher dosages and/or frequent dosing of gabapentin may be needed to maintain targeted plasma concentrations in young HSs. Additional studies to investigate the clinical efficacy of gabapentin in veterinary species are warranted, and clinical discretion should be used when applying these results to patients outside of the specific demographic group studied here.
Authors
- Heather K. Knych (ORCID: https://orcid.org/0000-0002-8676-4970)
- Tess Rooney (ORCID: https://orcid.org/0000-0003-3152-0810)
- Cara L. Field (ORCID: https://orcid.org/0000-0001-9283-0199)
- Jenessa Gjeltema (ORCID: https://orcid.org/0000-0002-4566-3444)
- Mattison Peters (ORCID: https://orcid.org/0000-0003-0645-4233)
Institutions
- Marine Mammal Center (US)
- Zoological Society of San Diego (US)
- University of California, Davis (US)
Publication Details
- Journal
- American Journal of Veterinary Research
- Published
- 2025-09-05
- DOI
- https://doi.org/10.2460/ajvr.25.05.0178
- Primary Topic
- Neuropeptides and Animal Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00