Detection of lung allograft injury through a comprehensive multidisciplinary analysis of donor-derived cell-free DNA in plasma and bronchoalveolar lavage: a real-world single center experience
Our data suggests that plasma dd-cfDNA is a useful tool for immunological graft injury assessment. The performance of BAL dd-cf DNA needs to be validated on larger case series. The integration of plasma dd-cfDNA with other post-transplant follow-up investigations may allow more sensitive diagnoses and appropriate graft injury management.
Authors
- Davide Biondini (ORCID: https://orcid.org/0000-0002-0726-0812)
- Cecilia De Chellis
- Fausto Braccioni (ORCID: https://orcid.org/0000-0002-7197-9821)
- Luca Vedovelli (ORCID: https://orcid.org/0000-0003-4847-2333)
- Federica Meloni (ORCID: https://orcid.org/0000-0003-4014-0617)
- Chiara Giraudo (ORCID: https://orcid.org/0000-0003-0924-5883)
- Federica Pezzuto (ORCID: https://orcid.org/0000-0002-8023-3108)
- Federico Rea (ORCID: https://orcid.org/0000-0001-7988-5101)
- Eleonora Faccioli (ORCID: https://orcid.org/0000-0002-2095-5678)
- Serena Marinello (ORCID: https://orcid.org/0000-0001-8255-6763)
- Claudia Del Vecchio (ORCID: https://orcid.org/0000-0001-5645-9126)
- Deborah J. Levine (ORCID: https://orcid.org/0000-0002-2021-2233)
- Marta Vadori (ORCID: https://orcid.org/0000-0002-9763-2383)
- Francesca Lunardi (ORCID: https://orcid.org/0000-0001-5792-4683)
- Marco Schiavon (ORCID: https://orcid.org/0000-0003-4817-6067)
- Fiorella Calabrese
- Emanuele Cozzi
- Monica Loy
Institutions
- University of Padua (IT)
- Palo Alto University (US)
- Pulmonary and Allergy Associates (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1619771
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute
- Università degli Studi di Padova