High transposable element expression in sarcomas is associated with increased immune infiltrates and improved outcomes including after immunotherapy
TE and <i>IKZF1</i> expression warrant further translational investigation as potential biomarkers of tumor immune infiltrates and outcomes following ICI treatment, and as therapeutic targets in sarcomas.
Authors
- Emily Kanaya Slotkin (ORCID: https://orcid.org/0000-0002-4463-5759)
- Allison L. Richards (ORCID: https://orcid.org/0000-0003-2312-2302)
- Viswatej Avutu (ORCID: https://orcid.org/0000-0002-2591-7187)
- Ping Chi
- Travis E. Adamson (ORCID: https://orcid.org/0000-0001-5055-0842)
- Lauren B. Banks (ORCID: https://orcid.org/0000-0002-3443-6414)
- William D. Tap (ORCID: https://orcid.org/0000-0001-7779-2796)
- Mrinal M. Gounder (ORCID: https://orcid.org/0000-0001-8468-0119)
- Mark T.A. Donoghue (ORCID: https://orcid.org/0000-0003-4538-6069)
- Jason E. Chan (ORCID: https://orcid.org/0000-0003-0552-8544)
- Mark A. Dickson (ORCID: https://orcid.org/0000-0003-2764-751X)
- Benjamin A. Nacev (ORCID: https://orcid.org/0000-0003-4991-2492)
- Evan Rosenbaum (ORCID: https://orcid.org/0000-0002-7499-1279)
- Martina Bradić (ORCID: https://orcid.org/0000-0001-6078-5311)
- Sujana Movva (ORCID: https://orcid.org/0000-0002-6569-6606)
- Robert G. Maki (ORCID: https://orcid.org/0000-0002-9853-2528)
- Samuel Singer (ORCID: https://orcid.org/0000-0001-9713-8230)
- Ciara M. Kelly (ORCID: https://orcid.org/0000-0002-4393-8088)
- Cristina R. Antonescu (ORCID: https://orcid.org/0000-0002-9717-8205)
- Sandra P. D’Angelo (ORCID: https://orcid.org/0000-0002-3736-3783)
- Hyung Jun Woo (ORCID: https://orcid.org/0000-0003-3220-2064)
- Mary Lou Keohan
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- University of Pittsburgh (US)
- Cornell University (US)
- UPMC Hillman Cancer Center (US)
- Molecular Oncology (United States) (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1136/jitc-2025-012357
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Damon Runyon Cancer Research Foundation
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- GlaxoSmithKline
- Merck
- Memorial Sloan-Kettering Cancer Center
- Regeneron Pharmaceuticals
- Connective Tissue Oncology Society
- Cycle for Survival
- Incyte
- Ascentage Pharma
- Servier
- Plexxikon
- National Institutes of Health
- EMD Serono
- Foundation Medicine
- National Cancer Institute
- Daiichi Sankyo Europe