Figure 7 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
<p>Activity of RMC-6236 in pancreatic and lung cancer patients. <b>A,</b> Pretreatment and 12-week (post cycle 4) scans of a heavily pretreated patient with a <i>KRAS</i><sup>G12D</sup> mutation-positive PDAC indicating a complete response of both target and nontarget lesions. Patient continued on study treatment in cycle 6. Axial views of computed tomography (CT) abdomen images prior to RMC-6236 treatment (top) and after four cycles of RMC-6236 treatment (bottom). <b>B,</b> Pretreatment and 6-week (post cycle 2) scans of a patient with a <i>KRAS</i><sup>G12V</sup> mutation-positive NSCLC indicating a complete response of target lesions (no nontarget lesions present at baseline), atelectatic changes in the right lung are also largely resolved by 6 weeks. Complete response was confirmed at cycle 4, and the patient continued on study treatment with a complete response in cycle 10. Axial views of computed tomography (CT) chest images prior to RMC-6236 treatment (top) and after two cycles of RMC-6236 treatment (bottom).</p>
Authors
- Xing Wei (ORCID: https://orcid.org/0000-0002-4584-3891)
- Abby Reed (ORCID: https://orcid.org/0009-0008-0689-5817)
- James Cregg (ORCID: https://orcid.org/0000-0002-2871-0800)
- Marie Ménard (ORCID: https://orcid.org/0000-0003-1511-4361)
- Abby Marquez (ORCID: https://orcid.org/0000-0001-5104-2823)
- Benjamin J. Maldonato (ORCID: https://orcid.org/0000-0001-6560-0224)
- Zeena Salman (ORCID: https://orcid.org/0009-0009-3887-1542)
- Zhengping Wang (ORCID: https://orcid.org/0009-0000-8127-9063)
- Dylan Parsons (ORCID: https://orcid.org/0000-0001-5142-3829)
- Matthew Holderfield (ORCID: https://orcid.org/0000-0001-8474-3220)
- Adrian L. Gill (ORCID: https://orcid.org/0009-0003-0914-4860)
- Elsa Quintana (ORCID: https://orcid.org/0000-0002-4123-1695)
- James W. Evans (ORCID: https://orcid.org/0009-0005-0401-6397)
- Jacqueline A.M. Smith (ORCID: https://orcid.org/0000-0001-5028-8725)
- Ian P. Winters (ORCID: https://orcid.org/0000-0002-3497-3228)
- Yingyun Wang (ORCID: https://orcid.org/0009-0006-6917-0245)
- David Wildes (ORCID: https://orcid.org/0009-0009-3855-7270)
- Kyle J. Seamon (ORCID: https://orcid.org/0009-0005-5028-3752)
- Elena S. Koltun (ORCID: https://orcid.org/0009-0005-8720-9097)
- John E. Knox (ORCID: https://orcid.org/0009-0006-6246-5198)
- Kathryn C. Arbour (ORCID: https://orcid.org/0000-0001-5951-8427)
- Michael Rosen (ORCID: https://orcid.org/0000-0002-8842-6692)
- Aidan C.A. Tomlinson (ORCID: https://orcid.org/0000-0002-9663-773X)
- Jingjing Jiang (ORCID: https://orcid.org/0009-0004-2766-025X)
- Zhican Wang (ORCID: https://orcid.org/0000-0002-9411-9349)
- Jason K. Yano (ORCID: https://orcid.org/0000-0002-9774-2611)
- Mallika Singh (ORCID: https://orcid.org/0009-0003-0234-1589)
- Stephanie Chang (ORCID: https://orcid.org/0009-0000-2026-5215)
- Zhe Chen (ORCID: https://orcid.org/0000-0003-3626-9848)
- Cristina Blaj (ORCID: https://orcid.org/0000-0003-0449-2690)
- Ida Aronchik (ORCID: https://orcid.org/0009-0002-1590-8778)
- Andrew J. Aguirre (ORCID: https://orcid.org/0000-0002-0701-6203)
- W. Clay Gustafson (ORCID: https://orcid.org/0000-0002-1812-5675)
- Yevgeniy Gindin (ORCID: https://orcid.org/0000-0001-8694-6849)
- Lingyan Jiang (ORCID: https://orcid.org/0009-0006-7523-6968)
- Jens Brodbeck (ORCID: https://orcid.org/0009-0001-6889-2987)
- Bianca J. Lee (ORCID: https://orcid.org/0009-0000-4888-8684)
Publication Details
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1158/2159-8290.30062240
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00