Palladium-Catalyzed Carbonylative Synthesis of Amide-Containing 3,4-Dihydroisoquinolin-1(2<i>H</i>)-ones from <i>N</i>-Propargylamides
A palladium-catalyzed cyclization and carbonylation of <i>N</i>-propargylamides with amines has been developed, which incorporates an amide unit into 3,4-dihydroisoquinolin-1(2<i>H</i>)-one scaffolds. By using benzene-1,3,5-triyl triformate (TFBen) as the safe and convenient CO source, the reaction proceeded smoothly to afford a variety of amide-containing 3,4-dihydroisoquinolin-1(2<i>H</i>)-one derivatives in high yields.
Authors
- Jun Ying (ORCID: https://orcid.org/0000-0002-9578-2863)
- Wei Chen (ORCID: https://orcid.org/0000-0001-9527-110X)
- Jianwei Wang (ORCID: https://orcid.org/0000-0002-6094-376X)
- Yan Cao (ORCID: https://orcid.org/0000-0001-7866-1640)
- Xiaolong Wang (ORCID: https://orcid.org/0000-0003-1620-1344)
- Shuwei Li (ORCID: https://orcid.org/0000-0002-4524-6608)
- Linqi Wang (ORCID: https://orcid.org/0009-0006-3179-6592)
Institutions
- Zhejiang Sci-Tech University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1021/acs.joc.5c01621
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Zhejiang Sci-Tech University