Evolutionary analysis of CD300A and CD300C paired receptors in primates

These contrasting patterns suggest that while CD300A plays an essential and irreplaceable role in immune regulation, the activating function of CD300C may be context-dependent or dispensable. Additionally, we identified evidence of gene conversion between CD300A and CD300C in several lineages, preserving extracellular domain similarity despite divergent signaling functions. Our findings highlight the complex evolutionary dynamics of the CD300 gene family and provide new insights into how primate immune systems adapt.