Perioperative Collagen IV-Targeted Ac2-26 Nanoparticles Enhance Anastomotic Healing in Acute Crohn’s Disease-Like Colitis
(pc)-Col-IV-Ac2-26-NPs promote anastomotic healing during CD-colitis through targeted, route-dependent immunomodulation and tissue repair, with rectal delivery showing the highest local efficacy. These findings support their potential as locally acting, non-immunosuppressive therapy for high-risk CD-patients undergoing intestinal surgery.
Authors
- Helmut Friess
- Thomas J. Metzler (ORCID: https://orcid.org/0000-0002-1620-5559)
- Stefan Reischl (ORCID: https://orcid.org/0000-0001-7341-4296)
- Zoé Clees
- Kamacay Cira (ORCID: https://orcid.org/0000-0002-2026-2978)
- Vincent Vieregge (ORCID: https://orcid.org/0000-0003-2114-8736)
- Robert Leon Walter (ORCID: https://orcid.org/0000-0002-7088-736X)
- Sebastian Pollak
- Nazila Kamaly (ORCID: https://orcid.org/0000-0002-9716-5121)
- Philipp‐Alexander Neumann (ORCID: https://orcid.org/0000-0001-8361-3934)
- Atsuko Kasajima (ORCID: https://orcid.org/0000-0002-1130-1744)
- Jong‐Hyun Lee (ORCID: https://orcid.org/0000-0001-6546-973X)
Institutions
- TUM Klinikum (DE)
- Imperial College London (GB)
- Technical University of Munich (DE)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Annals of Surgery
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1097/sla.0000000000006929
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00