Ni-Catalyzed [2 + 2 + 2] Cycloaddition via the Capture of Azametallacyclopentadienes with Allyl Boronate: Facile Access to Fused Pyridine Derivatives
An unprecedented nickel-catalyzed [2 + 2 + 2] cycloaddition that enables efficient construction of fused pyridine frameworks with allyl boronate was reported. This transformation is proposed to occur through a mechanism involving aza-nickelacyclopentadiene intermediates, wherein the boryl group of the allyl boronate plays a critical role in enabling the following cyclization via the control experiments. This work not only expands the structural diversity accessible via transition-metal-catalyzed [2 + 2 + 2] cycloadditions but also showcases the untapped potential of unsaturated substrates in cycloaddition reactions.
Authors
- Jiuzhong Huang (ORCID: https://orcid.org/0000-0002-6474-7707)
- Tongtong Shi
- Ke‐Si Du
- S.Z. Hu (ORCID: https://orcid.org/0009-0006-4854-210X)
- Ruihuan Gao (ORCID: https://orcid.org/0009-0000-1960-8399)
- Tao Zhu (ORCID: https://orcid.org/0000-0002-6395-5598)
- Zhao‐Yang Wang (ORCID: https://orcid.org/0000-0002-2391-5938)
- Guangyu Li (ORCID: https://orcid.org/0000-0001-5172-9676)
- Chunsheng Li (ORCID: https://orcid.org/0000-0003-1479-6831)
Institutions
- Guiyang Medical University (CN)
- Zhaoqing University (CN)
- South China Normal University (CN)
- Gannan Medical University (CN)
Publication Details
- Journal
- Molecules
- Published
- 2025-09-05
- DOI
- https://doi.org/10.3390/molecules30173629
- Citations
- 2
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province