Bufalin Suppresses Colorectal Cancer Liver Metastasis by Inhibiting De Novo Fatty Acid Synthesis via the PI3K/AKT-Mediated SREBP1/FASN Pathway
Bufalin inhibits de novo fatty acid synthesis via the PI3K/AKT-mediated SREBP1/FASN pathway, suppressing CRC progression and liver metastasis.
Authors
- Chunze Zhang (ORCID: https://orcid.org/0000-0002-2063-5631)
- Suying Yan
- Wenwen Pang (ORCID: https://orcid.org/0000-0002-3892-8707)
- Ping Wu (ORCID: https://orcid.org/0000-0003-2397-2761)
- Bowei Zhang (ORCID: https://orcid.org/0009-0000-9686-0897)
- Xiang Li (ORCID: https://orcid.org/0009-0008-1868-0039)
- Haiyang Yu (ORCID: https://orcid.org/0000-0002-6492-7687)
- Junshi Zhang (ORCID: https://orcid.org/0000-0002-0092-9843)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Nankai University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Molecules
- Published
- 2025-09-05
- DOI
- https://doi.org/10.3390/molecules30173634
- Citations
- 1
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Tianjin Municipal Health Commission